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MPPA

Chemical Structure : MPPA

CAS No.: 2229897-74-7

MPPA (Dual sEH/PDE4 inhibitor MPPA)

Catalog No.: PC-63331Not For Human Use, Lab Use Only.

MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively.
    MPPA reduces inflammatory pain in lipopolysaccharide induced inflammatory pain rat model.

    Physicochemical Properties

    M.Wt 372.388
    Formula C18H23F3N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(4-methoxy-2-(trifluoromethyl)benzyl)-1-propionylpiperidine-4-carboxamide

    References

    1. Blöcher R, et al. J Med Chem. 2018 Apr 10. doi: 10.1021/acs.jmedchem.7b01804.

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