MPT0B002 |CAS:946077-08-3 Probechem Biochemicals

Chemical Structure : MPT0B002

MPT0B002 (MPT0B-002;MPT0B 002)

Catalog No.: PC-60553Not For Human Use, Lab Use Only.

MPT0B002 is a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.

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Biological Activity

MPT0B002 is a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.
MPT0B002 disrupts tubulin polymerization and arrests cell cycle at the G2/M phase.
MPT0B002 induces apoptosis associated with increased levels of cleaved caspase-3 and cleaved PARP.

Physicochemical Properties

M.Wt	325.36
Formula	C19H19NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxy-phenyl)-methanone

References

1. Yeh YY, et al. Invest New Drugs. 2017 Aug;35(4):427-435.

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MPT0B002 (MPT0B-002;MPT0B 002)

Biological Activity

Physicochemical Properties

References

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