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Chemical Structure : MRGPRX1 inhibitor 1t
Catalog No.: PC-72741Not For Human Use, Lab Use Only.
MRGPRX1 inhibitor 1t is a potent, selective, positive allosteric modulator (PAM) of Mas-related G protein-coupled receptor X1 (MRGPRX1) with EC50 of 0.1 uM.
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MRGPRX1 inhibitor 1t is a potent, selective, positive allosteric modulator (PAM) of Mas-related G protein-coupled receptor X1 (MRGPRX1) with EC50 of 0.1 uM.
MRGPRX1 inhibitor 1t can be distributed to the spinal cord, the presumed site of action, following oral administration.
In a neuropathic pain model induced by sciatic nerve chronic constriction injury (CCI), compound 1t (100 mg/kg, po) reduced behavioral heat hypersensitivity in humanized MRGPRX1 mice.
Mas-related G protein-coupled receptor X1 (MRGPRX1) is a human sensory neuron-specific receptor and potential target for the treatment of pain.
| M.Wt | 513.356 | |
| Formula | C23H17Cl2F3N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ilyas Berhane, et al. J. Med. Chem. 2022
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