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Chemical Structure : MRK-003
Catalog No.: PC-70070Not For Human Use, Lab Use Only.
MRK-003 (MRK003) is a potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.
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MRK-003 (MRK003) is a potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.
MRK-003 inhibits the γ-secretase-mediated cleavage of the Notch receptor, reduces tumor cell proliferation, inhibits serum independence, and induces apoptosis in vitro and in vivo using mouse xenograft models.
| M.Wt | 551.59 | |
| Formula | C25H31F6N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lewis HD, et al. Chem Biol. 2007 Feb;14(2):209-19.
2. Sparey T, et al. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4212-6.
3. Konishi J, et al. Cancer Res. 2007 Sep 1;67(17):8051-7.
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