MRK-003 |CAS:623165-93-5 Probechem Biochemicals

Chemical Structure : MRK-003

MRK-003 (MRK 003;MRK003)

Catalog No.: PC-70070Not For Human Use, Lab Use Only.

MRK-003 (MRK003) is a potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.

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Biological Activity

MRK-003 (MRK003) is a potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.
MRK-003 inhibits the γ-secretase-mediated cleavage of the Notch receptor, reduces tumor cell proliferation, inhibits serum independence, and induces apoptosis in vitro and in vivo using mouse xenograft models.

Physicochemical Properties

M.Wt	551.59
Formula	C25H31F6N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,6'S,9'R)-5-(2,2,2-trifluoroethyl)-2'-((E)-3-(4-(trifluoromethyl)piperidin-1-yl)prop-1-en-1-yl)-5',6',7',8',9',10'-hexahydrospiro[[1,2,5]thiadiazolidine-3,11'-[6,9]methanobenzo[8]annulene] 1,1-dioxide

References

1. Lewis HD, et al. Chem Biol. 2007 Feb;14(2):209-19.

2. Sparey T, et al. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4212-6.

3. Konishi J, et al. Cancer Res. 2007 Sep 1;67(17):8051-7.

MRK-003 (MRK 003;MRK003)

Biological Activity

Physicochemical Properties

References

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