Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MRK-1
Catalog No.: PC-23259Not For Human Use, Lab Use Only.
MRK-1 is a small molecule non-nucleoside inhibitor of the RSV L polymerase protein, binds to the RNA-dependent RNA polymerase (RdRp, L-polymerase) and inhibits vRNA synthesis initiation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MRK-1 is a small molecule non-nucleoside inhibitor of the RSV L polymerase protein, binds to the RNA-dependent RNA polymerase (RdRp, L-polymerase) and inhibits vRNA synthesis initiation.
MRK-1 exhibits antiviral activity in cell-based viral replication assays with antiviral potency against RSV-A2/EGFP (EC50 = 2.1nM) in a GFP reporter assay, the lab-adapted strains RSV-A Long (EC50 = 3.9nM) and 74 RSV-B Washington (EC50 = 3.3nM) in plaque reduction assays (PRA), and the clinical isolates RSV-A (EC50 = 4.3nM) and RSV-B (EC50 = 1.3nM) in cytopathic effect assays.
| M.Wt | 478.52 | |
| Formula | C26H27FN4O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Citron MP, et al. J Infect. 2024 Oct 23:106325.
2. Kleiner VA, et al. Commun Biol. 2023 Jun 19;6(1):649.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
