Chemical Structure : MRK-1
CAS No.:
MRK-1
(MRK1)
Catalog No.: PC-23259Not For Human Use, Lab Use Only.
MRK-1 is a small molecule non-nucleoside inhibitor of the RSV L polymerase protein, binds to the RNA-dependent RNA polymerase (RdRp, L-polymerase) and inhibits vRNA synthesis initiation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MRK-1 is a small molecule non-nucleoside inhibitor of the RSV L polymerase protein, binds to the RNA-dependent RNA polymerase (RdRp, L-polymerase) and inhibits vRNA synthesis initiation.
MRK-1 exhibits antiviral activity in cell-based viral replication assays with antiviral potency against RSV-A2/EGFP (EC50 = 2.1nM) in a GFP reporter assay, the lab-adapted strains RSV-A Long (EC50 = 3.9nM) and 74 RSV-B Washington (EC50 = 3.3nM) in plaque reduction assays (PRA), and the clinical isolates RSV-A (EC50 = 4.3nM) and RSV-B (EC50 = 1.3nM) in cytopathic effect assays.
Physicochemical Properties
|
M.Wt
|
478.52
|
|
Formula
|
C26H27FN4O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-(2-aminopropan-2-yl)-N'-(4-cyclopropoxy-3-methoxybenzoyl)-6-(4-fluorophenyl)picolinohydrazide
|
References
1. Citron MP, et al. J Infect. 2024 Oct 23:106325.
2. Kleiner VA, et al. Commun Biol. 2023 Jun 19;6(1):649.
Contact Us
sales@probechem.com
