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Chemical Structure : MRK-560
CAS No.: 677772-84-8
Catalog No.: PC-62921Not For Human Use, Lab Use Only.
MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.
MRK-560 inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with IC50 of 0.65 nM.
MRK-560 reduces levels of Aβ in the brain and cerebrospinal fluid (CSF) in rats with ED50 of 6 and 10 mg/kg.
| M.Wt | 517.91 | |
| Formula | C19H17ClF5NO4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
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1. Best JD, et al. J Pharmacol Exp Ther. 2006 May;317(2):786-90.
2. Best JD, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8.
3. Wang FH, et al. Eur J Neurosci. 2012 Nov;36(9):3165-72.
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