Chemical Structure : MRK-560
CAS No.:
677772-84-8
MRK-560
(MRK560)
Catalog No. : PC-62921Not For Human Use, Lab Use Only.
MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6292101
Biological Activity
MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.
Physicochemical Properties
M.Wt
517.91
Formula
C19H17ClF5NO4S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
References
1. Best JD, et al. J Pharmacol Exp Ther.
2. Best JD, et al. J Pharmacol Exp Ther.
3. Wang FH, et al. Eur J Neurosci.
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