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MRL-1237

Chemical Structure : MRL-1237

CAS No.: 276704-21-3

MRL-1237 (MRL1237)

Catalog No.: PC-62926Not For Human Use, Lab Use Only.

MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein.
    MRL-1237 inhibits poliovirus-specific RNA synthesis in HeLa cells infected with a wild strain but not with an F164Y mutant.

    Physicochemical Properties

    M.Wt 354.813
    Formula C19H16ClFN4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-((1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)methyl)pyridin-4(1H)-imine hydrochloride

    References

    1. Shimizu H, et al. J Virol. 2000 May;74(9):4146-54.

    2. De Palma AM, et al. J Virol. 2008 May;82(10):4720-30.

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