Chemical Structure : MRL-494 hydrochloride
CAS No.:
2699937-04-5
MRL-494 hydrochloride
Catalog No.: PC-26828Not For Human Use, Lab Use Only.
MRL-494 hydrochloride (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MRL-494 hydrochloride (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
MRL-494 exhibited antimicrobial activity against a broad range of bacterial species, impairs biogenesis of OMPs and potentiates rifampicin.
MRL-494 impairs biogenesis of OMPs, BamAE470K provides resistance to MRL-494 and restores OMP biogenesis.
MRL-494 inhibits Gram-positive and -negative microbes through distinct mechanisms of action.
Physicochemical Properties
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M.Wt
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659.13
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Formula
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C26H36ClFN16O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-carbamimidoyl-3-cyclopropyl-3-((4-((4-(2-(5-(4-fluorophenyl)-2H-tetrazol-2-yl)acetamido)cyclohexyl)amino)-6-guanidino-1,3,5-triazin-2-yl)amino)propanamide hydrochloride
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References
1. Elizabeth M Hart, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21748-21757.
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