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MRS7292

Chemical Structure : MRS7292

CAS No.: 2092913-97-6

MRS7292 (MRS-7292)

Catalog No.: PC-22973Not For Human Use, Lab Use Only.

MRS7292 is an allosteric, non-competitive inhibitor of human dopamine transporter (DAT) with EC50 of 35 nM, and norepinephrine transporter (NET), also is a potent A3AR agonist with Ki of 5.38 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MRS7292 is an allosteric, non-competitive inhibitor of human dopamine transporter (DAT) with EC50 of 35 nM, and norepinephrine transporter (NET), also is a potent A3AR agonist with Ki of 5.38 nM.

Physicochemical Properties

M.Wt 459.91
Formula C20H18ClN5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methyl (1S,2R,3S,4R,5S)-4-(2-((5-chlorothiophen-2-yl)ethynyl)-6-(methylamino)-9H-purin-9-yl)-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate

References

1. Tosh DK, et al. J Med Chem. 2017 Apr 13;60(7):3109-3123.

2. Srivastava DK, et al. Nature. 2024 Aug;632(8025):672-677.

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