MRS7292 | DAT inhibitor | Probechem Biochemicals

Chemical Structure : MRS7292

MRS7292 (MRS-7292)

Catalog No.: PC-22973Not For Human Use, Lab Use Only.

MRS7292 is an allosteric, non-competitive inhibitor of human dopamine transporter (DAT) with EC50 of 35 nM, and norepinephrine transporter (NET), also is a potent A3AR agonist with Ki of 5.38 nM.

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Biological Activity

MRS7292 is an allosteric, non-competitive inhibitor of human dopamine transporter (DAT) with EC50 of 35 nM, and norepinephrine transporter (NET), also is a potent A3AR agonist with Ki of 5.38 nM.

Physicochemical Properties

M.Wt	459.91
Formula	C20H18ClN5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (1S,2R,3S,4R,5S)-4-(2-((5-chlorothiophen-2-yl)ethynyl)-6-(methylamino)-9H-purin-9-yl)-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate

References

1. Tosh DK, et al. J Med Chem. 2017 Apr 13;60(7):3109-3123.

2. Srivastava DK, et al. Nature. 2024 Aug;632(8025):672-677.

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MRS7292 (MRS-7292)

Biological Activity

Physicochemical Properties

References

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