Chemical Structure : MRT-31619
CAS No.:
MRT-31619
(MRT31619)
Catalog No.: PC-25736Not For Human Use, Lab Use Only.
MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation.
MRT-31619 outperforms the CRBN homo-PROTAC in terms of potency, selectivity and speed.
MRT-31619 exhibits an excellent selectivity profile at 1-10 uM, including several known CRBN neosubstrates are degraded by the CRBN homo-PROTAC (ZFP91, ZNF692, ZNF653, RNF166, IKZF1).
MRT-31619 binds CRBN with IC50 of 14 nM in biochemical thalidomide CRBN displacement assays and promotes its degradation by ubiquitin-proteasome system (UPS).
Physicochemical Properties
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M.Wt
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486.57
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Formula
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C28H30N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(6-(8-benzoyl-2,8-diazaspiro[4.5]decan-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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References
1. Langousis G, et al. Nat Commun. 2025 Nov 19;16(1):10157.
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