MRT-5702D

Chemical Structure : MRT-5702D

Catalog No.: PC-26773Not For Human Use, Lab Use Only.

MRT-5702D is a specific molecular glue degrader targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation.

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Biological Activity

MRT-5702D is a specific molecular glue degrader targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation.

Physicochemical Properties

M.Wt	621.11
Formula	C30H29ClN6O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S)-2-((2-chlorobenzyl)sulfonyl)-N-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)imidazo[1,2-a]pyridin-7-yl)methyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

References

1. Annunziato S, et al. Nat Struct Mol Biol. 2026 Mar;33(3):479-487.

2. Annunziato S, et al. bioRxiv, 2025: 2025.04. 30.651496.

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MRT-5702D

Biological Activity

Physicochemical Properties

References

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