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MRT68921

Chemical Structure : MRT68921

CAS No.: 1190379-70-4

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MRT68921 (MRT-68921, MRT 68921)

Catalog No.: PC-42020Not For Human Use, Lab Use Only.

MRT-68921 is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.

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10 mg $88 In stock
25 mg $148 In stock
50 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MRT68921 is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
MRT68921 inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK.
MRT68921 reduces phospho-ATG13 and blocks autophagy in cells.

Physicochemical Properties

M.Wt 434.5771
Formula C25H34N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-

References

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

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