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MS-377

Chemical Structure : MS-377

CAS No.: 206862-30-8

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MS-377 (MS377)

Catalog No.: PC-63205Not For Human Use, Lab Use Only.

MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.
    MS-377  markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain.

    Physicochemical Properties

    M.Wt 351.875
    Formula C18H26ClN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(4-chlorophenyl)-3-((4-(2-methoxyethyl)piperazin-1-yl)methyl)pyrrolidin-2-one

    References

    1. Takahashi S, et al. Psychopharmacology (Berl). 1999 Aug;145(3):295-302.

    2. Karasawa J, et al. Eur J Pharmacol. 2000 Jul 14;400(1):51-7.

    3. Yamada S, et al. Eur J Pharmacol. 2000 Aug 25;402(3):251-4.

    4. Takahashi S, et al. Eur J Pharmacol. 2001 Sep 21;427(3):211-9.

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