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Chemical Structure : MS-377
Catalog No.: PC-63205Not For Human Use, Lab Use Only.
MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.
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MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.
MS-377 markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain.
| M.Wt | 351.875 | |
| Formula | C18H26ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takahashi S, et al. Psychopharmacology (Berl). 1999 Aug;145(3):295-302.
2. Karasawa J, et al. Eur J Pharmacol. 2000 Jul 14;400(1):51-7.
3. Yamada S, et al. Eur J Pharmacol. 2000 Aug 25;402(3):251-4.
4. Takahashi S, et al. Eur J Pharmacol. 2001 Sep 21;427(3):211-9.
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