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Chemical Structure : MS-444
CAS No.: 150045-18-4
Catalog No.: PC-60907Not For Human Use, Lab Use Only.
MS-444 (BE-34776) is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote |
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MS-444 (BE-34776) is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM.
MS-444 interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation, and is a valuable tool for studying HuR function.
MS-444 augmentes DSS-induced weight loss and increases tumor multiplicity, size, and invasiveness in mice model of inflammatory colon cancer, also abrogates tumor cell apoptosis and depletes tumor-associated eosinophils, accompanied by a decrease in IL18 and eotaxin-1.
| M.Wt | 230.21 | |
| Formula | C13H10O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,8-Dihydroxy-3-methyl-naphtho[2,3-c]furan-4(9H)-one |
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1. Meisner NC, et al. Nat Chem Biol. 2007 Aug;3(8):508-15.
2. Blanco FF, et al. Oncotarget. 2016 Nov 8;7(45):74043-74058.
3. Lang M, et al. Cancer Res. 2017 May 1;77(9):2424-2438.
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