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Chemical Structure : MS47134
CAS No.:
Catalog No.: PC-38069Not For Human Use, Lab Use Only.
MS47134 is a potent, selective MRGPRX4 agonist with EC50 of 149 nM.
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MS47134 is a potent, selective MRGPRX4 agonist with EC50 of 149 nM.
MS47134 displays 47-fold improved selectivity for MRGPRX4 over the Kir6.2/SUR1 potassium channel.
Off-target profiling of MS47134 at 320 GPCRs showed activity only at MRGPRX4 and MRG-PRX1 with no appreciable agonist or antagonist activity at the other 318 tested GPCRs.
MS47134 binds to MRGP RX4 on the extrac ellular side far from t he canonical to ggle switch W6.48 in 5-HT2AR.
A Y130ICL2A mutation reduced the agonist potency of MS47134 while the Y137ICL2A mutation in MRG-PRX2 has little effect.
| M.Wt | 355.478 | |
| Formula | C22H29NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3,5-dimethyladamantane-1-carbonyl)-D-phenylalanine |
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1. Can Cao, et al. Nature. 2021 Dec;600(7887):170-175.
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