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Chemical Structure : MS98
CAS No.: 2376137-31-2
Catalog No.: PC-22098Not For Human Use, Lab Use Only.
MS98 (AKT PROTAC degrader) is a potent, selective von Hippel-Lindau (VHL)-recruiting AKT PROTAC degrader with DC50 of 78 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $298 | In stock | |
| 5 mg | $498 | In stock | |
| 10 mg | $788 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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MS98 (AKT PROTAC degrader) is a potent, selective von Hippel-Lindau (VHL)-recruiting AKT PROTAC degrader with DC50 of 78 nM (cellular T-AKT in BT474 cells).
MS98 binds to AKT1, AKT2, and AKT3 with Kds of 4 nM, 140 nM, and 8.1 nM, respectively.
MS98 selectively induces robust AKT protein degradation, inhibits downstream signaling, and suppresses cancer cell proliferation.
MS98 is a useful chemical tool to investigate biological and pathogenic functions of AKT in vitro and in vivo.
| M.Wt | 1097.86 | |
| Formula | C58H81ClN10O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N1-(2-(((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)amino)ethyl)-N12-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)dodecanediamide |
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1. Yu X, et al. J Med Chem. 2021;64(24):18054-18081.
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