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MSA-2

Chemical Structure : MSA-2

CAS No.: 129425-81-6

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MSA-2 (MSA2)

Catalog No.: PC-73371Not For Human Use, Lab Use Only.

MSA-2 is a potent and orally available non-nucleotide STING agonist with EC50 of 8.3 and 24 uM for human STING isoforms WT and HAQ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MSA-2 is a potent and orally available non-nucleotide STING agonist with EC50 of 8.3 and 24 uM for human STING isoforms WT and HAQ, respectively.
MSA-2 exhibits antitumor activity and stimulates interferon-β secretion in tumors.
MSA-2 induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.

Physicochemical Properties

M.Wt 294.32
Formula C14H14O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid

References

1. Bo-Sheng Pan, et al. Science. 2020 Aug 21;369(6506):eaba6098.

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