MSC-1254 | TEAD1 inhibitor | Probechem Biochemicals

Chemical Structure : MSC-1254

MSC-1254 (MSC1254)

Catalog No.: PC-23232Not For Human Use, Lab Use Only.

MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM.

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Biological Activity

MSC-1254 is a potent, selective, reversible TEAD1 inhibitor with EC50 of 0.1 uM in TEAD-reporter assay in SK-Hep-1 cells, shows viability affect in NCI-H226 cell line with EC50 of 0.04 uM.
MSC-1254 shows cellular palmitoylation inhibition of TEAD1 in HEK-293 cells, but not TEAD2, TEAD3 and TEAD4.

Physicochemical Properties

M.Wt	512.53
Formula	C25H22F2N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1,1-dioxidothiomorpholino)-4-(4-fluorophenoxy)benzyl)-6-fluoroimidazo[1,2-a]pyridine-3-carboxamide

References

1. Carswell E, et al. Bioorg Med Chem Lett. 2024 Oct 4:129981.

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MSC-1254 (MSC1254)

Biological Activity

Physicochemical Properties

References

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