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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Monocarboxylate Transporter (MCT)-MSC-4381
MSC-4381

Chemical Structure : MSC-4381

CAS No.: 2445185-57-7

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MSC-4381 (MCT4 inhibitor 18n)

Catalog No.: PC-72709Not For Human Use, Lab Use Only.

MSC-4381 (MCT4 inhibitor 18n) is a potent, selective inhibitor of monocarboxylate transporter 4 (MCT4/SLC16A3).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MSC-4381 (MCT4 inhibitor 18n) is a potent, selective inhibitor of monocarboxylate transporter 4 (MCT4/SLC16A3).
In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells.
MCT4 inhibitor 18n demonstrated lactate modulation and antitumor activity in a mouse tumor model.

Physicochemical Properties

M.Wt 537.971
Formula C26H20ClN3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((5-chloro-2-((5-ethoxyquinoline)-8-sulfonamido)phenyl)ethynyl)-4-methoxypicolinic acid

References

1. Timo Heinrich, et al. J Med Chem. 2021 Aug 26;64(16):11904-11933.

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