MSD199 | Nav1.8 inhibitor | Probechem Biochemicals

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Chemical Structure : MSD199

MSD199 (MSD-199)

Catalog No.: PC-23138Not For Human Use, Lab Use Only.

MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
MSD199 (1, 3, and 10 mg/kg) dose-dependently reduced capsaicin-sensitized thermode (CST) response count.
MSD199 (1.3 mg/kg IV) dose-dependently prevented capsaicin flare propagation in vivo.
MSD199 (1.3 mg/kg) significantly reduced flare size at 1400 mA diode laser stimulation.

Physicochemical Properties

M.Wt	425.45
Formula	C18H21F2N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,4-difluoroazepan-1-yl)-6-methyl-N-(2-sulfamoylpyridin-4-yl)nicotinamide

References

1. Vardigan JD, et al. Pain. 2024 Oct 8. doi: 10.1097/j.pain.0000000000003404.

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MSD199 (MSD-199)

Biological Activity

Physicochemical Properties

References

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