Catalog No.: PC-23138Not For Human Use, Lab Use Only.
MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
MSD199 (1, 3, and 10 mg/kg) dose-dependently reduced capsaicin-sensitized thermode (CST) response count.
MSD199 (1.3 mg/kg IV) dose-dependently prevented capsaicin flare propagation in vivo.
MSD199 (1.3 mg/kg) significantly reduced flare size at 1400 mA diode laser stimulation.
