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MSD199 hydrochloride

Chemical Structure : MSD199 hydrochloride

CAS No.:

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MSD199 hydrochloride (MSD-199 hydrochloride)

Catalog No.: PC-23139Not For Human Use, Lab Use Only.

MSD199 hydrochloride is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MSD199 hydrochloride is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
MSD199 (1, 3, and 10 mg/kg) dose-dependently reduced capsaicin-sensitized thermode (CST) response count.
MSD199 (1.3 mg/kg IV) dose-dependently prevented capsaicin flare propagation in vivo.
MSD199 (1.3 mg/kg) significantly reduced flare size at 1400 mA diode laser stimulation.

Physicochemical Properties

M.Wt 461.91
Formula C18H22ClF2N5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4,4-difluoroazepan-1-yl)-6-methyl-N-(2-sulfamoylpyridin-4-yl)nicotinamide hydrochloride

References

1. Vardigan JD, et al. Pain. 2024 Oct 8. doi: 10.1097/j.pain.0000000000003404.

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