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Chemical Structure : MSD199 hydrochloride
Catalog No.: PC-23139Not For Human Use, Lab Use Only.
MSD199 hydrochloride is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
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MSD199 hydrochloride is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
MSD199 (1, 3, and 10 mg/kg) dose-dependently reduced capsaicin-sensitized thermode (CST) response count.
MSD199 (1.3 mg/kg IV) dose-dependently prevented capsaicin flare propagation in vivo.
MSD199 (1.3 mg/kg) significantly reduced flare size at 1400 mA diode laser stimulation.
| M.Wt | 461.91 | |
| Formula | C18H22ClF2N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vardigan JD, et al. ain. 2024 Oct 8. doi: 10.1097/j.pain.0000000000003404.
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