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MSNBA

Chemical Structure : MSNBA

CAS No.: 852702-51-3

MSNBA

Catalog No.: PC-25569Not For Human Use, Lab Use Only.

MSNBA is a specific inhibitor of glucose transporter GLUT5, competitively inhibits GLUT5 fructose uptake with Ki of 3.2 uM, inhibits GLUT5 fructose transport in proteoliposomes with IC50 of 0.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MSNBA is a specific inhibitor of glucose transporter GLUT5, competitively inhibits GLUT5 fructose uptake with Ki of 3.2 uM, inhibits GLUT5 fructose transport in proteoliposomes with IC50 of 0.1 uM.
MSNBA does not affect the fructose transport of human GLUT2 or the glucose transport of human GLUT1-4 or bacterial GlcPSe.
MSNBA potently inhibitsfructose uptake by GLUT5 in the human breast adenocarcinoma cell line MCF7 (IC50=5.8 uM).

Physicochemical Properties

M.Wt 336.32
Formula C14H12N2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Methanesulfonyl-2-nitrophenyl)-2H-1,3-benzodioxol-5-amine

References

1. George Thompson AM, et al. Sci Rep. 2016 Apr 14;6:24240.

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