Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MSU-43085
Catalog No.: PC-21545Not For Human Use, Lab Use Only.
MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
MSU-43085 is ~10-fold higher in potency than the clinically studied MmpL3 inhibitor SQ109 but ~3- to 5-fold lower than NITD-304 and NITD-349.
MSU-43085 exhibits potent growth inhibition of intracellular Mtb with EC50 of 134 nM.
MSU-43085 is potent against NTM species MAB and MAC with MICs of 2.9 and 23 µM against MAB and MAC, respectively.
MSU-43085 is active against drug-resistant Mtb strains.
MSU-43085 (200 mg/kg) is efficacious in an acute model of Mtb infection.
| M.Wt | 342.26 | |
| Formula | C16H21Cl2N3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
