Chemical Structure : MT-1207 hydrochloride
CAS No.:
1610794-70-1
MT-1207 hydrochloride
(MT1207 hydrochloride)
Catalog No.: PC-22599Not For Human Use, Lab Use Only.
MT-1027 hydrochloride is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MT-1027 hydrochloride is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively.
MT-1027 also shows high potency against adrenergic α1B (IC50 = 0.15 nM and Ki = 0.086 nM) and for adrenergic α1D (IC50 = 1.40 nM and Ki = 0.69 nM).
MT-1027 shows pA2 values of 7.98 ± 0.04 and 8.86 against noradrenaline and 5-HT-induced contraction in aortae.
MT-1027 has fewer side effects in a postural BP assay and could prevent the onset of postural hypotension.
Physicochemical Properties
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M.Wt
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428.98
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Formula
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C21H25ClN6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(4-(4-(1H-benzo[d][1,2,3]triazol-1-yl)butyl)piperazin-1-yl)benzo[d]isothiazole hydrochloride
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References
1. Wang P, et al. J Med Chem. 2024 Jul 5. doi: 10.1021/acs.jmedchem.4c00626.
2. Xu TY, et al. Acta Pharmacol Sin. 2021 Jun;42(6):885-897.
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