Chemical Structure : MT-DADMe-ImmA
CAS No.:
653592-04-2
MT-DADMe-ImmA
(Methylthio-DADMe-Immucillin A;MTDIA)
Catalog No. : PC-42402Not For Human Use, Lab Use Only.
A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4240201
Biological Activity
A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP ) with dissociation constant of 86 pM; increases cellular 5'-methylthioadenosine (MTA) concentrations, decreases polyamines, and induces apoptosis in head and neck squamous cell carcinoma cell lines.
Physicochemical Properties
M.Wt
293.38786
Formula
C13H19N5OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO
Chemical Name/SMILES
3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-
References
1. Basu I, et al. J Biol Chem.
2. Guan R, et al. Biochemistry.
3. Firestone RS, et al. ACS Chem Biol.
4. Singh V, et al. Biochemistry.
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