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MU135

Chemical Structure : MU135

CAS No.: 1821205-66-6

MU135

Catalog No.: PC-25697Not For Human Use, Lab Use Only.

MU135 is a potent, highly selective Homeodomain-interacting protein kinases (HIPKs) inhibitor with IC50 of 248/119/476 nM for HIPK1/HIPK12/HIPK13, repectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MU135 is a potent, highly selective Homeodomain-interacting protein kinases (HIPKs) inhibitor with IC50 of 248/119/476 nM for HIPK1/HIPK12/HIPK13, repectively.
MU135 is highly selective across the kinome in a broad panel of 373 human kinases, does not inhibits HIPK4 at 10 uM.

Physicochemical Properties

M.Wt 317.39
Formula C20H19N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-(tert-butyl)phenyl)-5-(1H-pyrazol-4-yl)furo[3,2-b]pyridine

References

1. Václav Němec, et al. Eur J Med Chem. 2021 Apr 5;215:113299.

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