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Chemical Structure : MU1700
Catalog No.: PC-72012Not For Human Use, Lab Use Only.
MU1700 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 13 and 6 nM, respectively.
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MU1700 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 13 and 6 nM, respectively.
MU1700 inhibits only ALK1/2/6 and no additional off targets by kinome-wide screening against 369 protein kinases at 1 uM.
MU1700 affects phosphorylation of SMAD1/5/8 that corresponds to BMP branch of signalling wchich is mediated also by ALK1/2 kinases.
MU1700 is suitable chemical probe for in vivo disease models, and has remarkably high brain penetrance (mice, PO, 100 mg/kg).
| M.Wt | 406.489 | |
| Formula | C26H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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