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MU1700

Chemical Structure : MU1700

CAS No.: 1360905-04-9

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MU1700 (MU 1700)

Catalog No.: PC-72012Not For Human Use, Lab Use Only.

MU1700 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 13 and 6 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MU1700 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 13 and 6 nM, respectively.
    MU1700 inhibits only ALK1/2/6 and no additional off targets by kinome-wide screening against 369 protein kinases at 1 uM.
    MU1700 affects phosphorylation of SMAD1/5/8 that corresponds to BMP branch of signalling wchich is mediated also by ALK1/2 kinases.
    MU1700 is suitable chemical probe for in vivo disease models, and has remarkably high brain penetrance (mice, PO, 100 mg/kg).

    Physicochemical Properties

    M.Wt 406.489
    Formula C26H22N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-(piperazin-1-yl)phenyl)-3-(quinolin-4-yl)furo[3,2-b]pyridine

    References

    1. Václav Němec, et al. J Med Chem. 2024 Aug 8;67(15):12632-12659.

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