Catalog No.: PC-61914Not For Human Use, Lab Use Only.
MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
MUT-A is a novel potent, HIV-1 integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
MUT-A interferes with the IN-LEDGF interaction during integration, shows no cellular toxicity in MT4 cells at 40 uM.
MUT-A inhibits IN (NL4-3)-LEDGF/p75 interaction with IC50 of 92 nM and promotes IN multimerization with activation constant AC50 of 55 nM.
MUT-A impairs virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
