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Chemical Structure : MUT-A
Catalog No.: PC-61914Not For Human Use, Lab Use Only.
MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
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MUT-A is a novel potent, HIV-1 integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
MUT-A interferes with the IN-LEDGF interaction during integration, shows no cellular toxicity in MT4 cells at 40 uM.
MUT-A inhibits IN (NL4-3)-LEDGF/p75 interaction with IC50 of 92 nM and promotes IN multimerization with activation constant AC50 of 55 nM.
MUT-A impairs virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
| M.Wt | 413.576 | |
| Formula | C24H31NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Amadori C, et al. Retrovirology. 2017 Nov 9;14(1):50.
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