MV1 |Cas:1001600-54-9 Probechem Biochemicals

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Chemical Structure : MV1

CAS No.: 1001600-54-9

MV1 (IAP antagonist MV1)

Catalog No.: PC-70207Not For Human Use, Lab Use Only.

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5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MV1 is a small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
MV1 induces cell death that is dependent on TNF signaling and de novo protein biosynthesis.

Physicochemical Properties

M.Wt	576.738
Formula	C33H44N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoate

References

1. Varfolomeev E, et al. Cell. 2007 Nov 16;131(4):669-81.

2. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.

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MV1 (IAP antagonist MV1)

Biological Activity

Physicochemical Properties

References

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