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MW-150 hydrochloride

Chemical Structure : MW-150 hydrochloride

CAS No.: 1923773-01-6

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MW-150 hydrochloride (MW01-18-150SRM, MW 150, MW150)

Catalog No.: PC-60432Not For Human Use, Lab Use Only.

MW-150 hydrochloride is a potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MW-150 hydrochloride is a potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM.
    MW-150 effectively suppresses hippocampal-dependent associative and spatial memory deficits in synaptic dysfunction mouse models.
    MW-150 also can selectively modulate neuroinflammatory responses associated with pathology progression.

    Physicochemical Properties

    M.Wt 417.94
    Formula C24H24ClN5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine hydrochloride

    References

    1. Roy SM, et al. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.

    2. Zhou Z, et al. J Neuroinflammation. 2017 Apr 5;14(1):75.

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