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Chemical Structure : MW181
Catalog No.: PC-62781Not For Human Use, Lab Use Only.
MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.
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MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.
MW181 suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production.
MW181 suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice.
MW181 significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.
| M.Wt | 326.403 | |
| Formula | C21H18N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.
2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.
3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.
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