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MW181

Chemical Structure : MW181

CAS No.: 1454658-87-7

MW181 (MW01-10-181SRM)

Catalog No.: PC-62781Not For Human Use, Lab Use Only.

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

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    Biological Activity

    MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.
    MW181 suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production.
    MW181 suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice.
    MW181 significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.

    Physicochemical Properties

    M.Wt 326.403
    Formula C21H18N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine

    References

    1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.

    2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.

    3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.

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