Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MW181 dihydrochloride
Catalog No.: PC-62783Not For Human Use, Lab Use Only.
MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ; suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production, suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice, significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.
2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.
3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
