MWAC-1657 | TREX1 inhibitor | Probechem Biochemicals

Chemical Structure : MWAC-1657

MWAC-1657 (MWAC1657 )

Catalog No.: PC-27257Not For Human Use, Lab Use Only.

MWAC-1657 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 154 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2.

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Biological Activity

MWAC-1657 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 154 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2.

Physicochemical Properties

M.Wt	399.45
Formula	C21H23F2N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,4-difluorophenyl)-1-(6-(1-ethyl-3-methyl-1H-pyrazol-4-yl)pyrazin-2-yl)piperidin-4-ol

References

1. Hernandez PC, et al. NAR Mol Med. 2026 Jun 19;3(3):ugag033.

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MWAC-1657 (MWAC1657 )

Biological Activity

Physicochemical Properties

References

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