Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MYF-01-37
CAS No.: 2416417-65-5
Catalog No.: PC-73155Not For Human Use, Lab Use Only.
MYF-01-37 (MYF-1-37) is a novel covalent TEAD inhibitor targeting Cys380, binds to palmitoylation pocket in TEAD1, targets YAP dependency upon combined EGFR/MEK inhibition.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MYF-01-37 (MYF-1-37) is a novel covalent TEAD inhibitor targeting Cys380, binds to palmitoylation pocket in TEAD1, targets YAP dependency upon combined EGFR/MEK inhibition.
MYF-01-37 (MYF-1-37) exhibits inhibition of direct YAP/TEAD interaction in HEK 293T cells and the reduction in canonical YAP target gene CTGF expression in PC-9 cells, this redcution effect was abrogated by the overexpression of TEAD1 C359S mutant that disrupts the covalent binding of the drug to TEAD, but not by overexpression of wild-type TEAD1.
MYF-01-37 (MYF-1-37) combined with OT completely suppressed the increased YAP activity induced by OT treatment in PC-9 YAP reporter cells, led to a robust increase in BMF expression, and to subsequent increase in apoptosis in PC-9 and HCC4006 cells compared to OT alone
| M.Wt | 298.309 | |
| Formula | C15H17F3N2O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(3-methyl-3-((3-(trifluoromethyl)phenyl)amino)pyrrolidin-1-yl)prop-2-en-1-one |
|
1. Kari J Kurppa, et al. Cancer Cell. 2020 Jan 13;37(1):104-122.e12.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
