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Chemical Structure : MYF-03-176
Catalog No.: PC-49407Not For Human Use, Lab Use Only.
MYF-03-176 is a potent and orally bioavailable MYF-03-69 analog, pan-TEAD inhibitor that disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=11 nM).
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MYF-03-176 is a potent and orally bioavailable MYF-03-69 analog, pan-TEAD inhibitor that disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=11 nM).
Similar to MYF-03-69, MYF-03-176 led to a significant downregulation of YAP target genes CTGF, CYR61, ANKRD1 and an upregulation of BMF.
MYF-03-176 exhibits antiproliferative effect in NCI-H226 cells with IC50 of 9 nM.
MYF-03-176 potently inhibited Hippo signaling defective MPM cells and suppresses tumor growth in mesothelioma xenograft mouse model.
| M.Wt | 410.373 | |
| Formula | C19H18F4N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mengyang Fan, et al. Elife. 2022 Oct 27;11:e78810.
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