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Chemical Structure : MYF-03-69
CAS No.: 2416418-11-4
Catalog No.: PC-49408Not For Human Use, Lab Use Only.
MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling.
MYF-03-69 is a pan-TEAD inhibitor, potently inhibits palmitoylation with similar IC50 values at submicromolar concentrations.
MYF-03-69 inhibits TEAD palmitoylation and disrupts endogenous YAP-TEAD association in cells.
MYF-03-69 inhibits TEAD transcription and downregulates YAP target genes expression in mesothelioma cells.
MYF-03-69 selectively inhibits proliferation of cancer cells with YAP or TEAD dependency regardless of lineage.
| M.Wt | 443.430 | |
| Formula | C22H20F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((3R,4R)-3-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)-4-((4-(trifluoromethyl)benzyl)oxy)pyrrolidin-1-yl)prop-2-en-1-one |
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1. Mengyang Fan, et al. Elife. 2022 Oct 27;11:e78810.
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