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MYLS22

Chemical Structure : MYLS22

CAS No.: 306959-01-3

MYLS22 (MYLS 22)

Catalog No.: PC-38609Not For Human Use, Lab Use Only.

MYLS22 is a specific, nontoxic small molecule inhibitor of the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1), curtails tumor growth and metastasisin vitro and in vivo.

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Biological Activity

MYLS22 is a specific, nontoxic small molecule inhibitor of the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1), curtails tumor growth and metastasisin vitro and in vivo.
MYLS22 downregulates the angiogenic factors (FGFR, FGF, EGF, and PDGF) used by tumors escaping from VEGF inhibitors.
MYLS22 (peritumoral injection 10 mg/kg/die) curtailed tumor growth, did not display any additive effect in Opa1+/ΔEC mice.
Pharmacological OPA1 inhibition via MYLS22 reduces breast cancer hallmarks in vitro.

Physicochemical Properties

M.Wt 443.52
Formula C24H21N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide

References

1. Herkenne S, et al. Cell Metab. 2020 May 5;31(5):987-1003.e8.

2. Corrado M, et al. Cell Death Differ. 2021 Jul;28(7):2194-2206.

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