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Macitentan

Chemical Structure : Macitentan

CAS No.: 441798-33-0

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Macitentan (ACT-064992, ACT064992)

Catalog No.: PC-25044Not For Human Use, Lab Use Only.

Macitentan (ACT-064992) is a potent, selective and orally active dual ETA/ETB endothelin receptor antagonist with binding IC50 of 0.5/391 nM for ETA/ETB receptors respectively.

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10 mg $38 In stock
25 mg $58 In stock
50 mg $88 In stock
100 mg $128 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Macitentan (ACT-064992) is a potent, selective and orally active dual ETA/ETB endothelin receptor antagonist with binding IC50 of 0.5/391 nM for ETA/ETB receptors respectively.

Physicochemical Properties

M.Wt 588.28
Formula C19H20Br2N6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N'-propylsulfamide

References

1. Iglarz M, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.

2. Bolli MH, et al. J Med Chem. 2012 Sep 13;55(17):7849-61.

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