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Macozinone

Chemical Structure : Macozinone

CAS No.: 1377239-83-2

Macozinone (PBTZ169, PBTZ-169)

Catalog No.: PC-61388Not For Human Use, Lab Use Only.

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

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Biological Activity

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.

Physicochemical Properties

M.Wt 456.484
Formula C20H23F3N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

References

1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.

2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.

3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.

4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.

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