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Chemical Structure : Madrasin
CAS No.: 374913-63-0
Catalog No.: PC-42098Not For Human Use, Lab Use Only.
A small molecule inhibitor of pre-mRNA splicing that interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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Madrasin (DDD00107587) is a small molecule inhibitor of pre-mRNA splicing that interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.
Madrasin induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
| M.Wt | 311.3385 | |
| Formula | C16H17N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl- |
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1. Pawellek A, et al. J Biol Chem. 2014 Dec 12;289(50):34683-98.
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