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Chemical Structure : Margetuximab
CAS No.:
Catalog No.: PC-Ab1036Not For Human Use, Lab Use Only.
Margetuximab (MGAH22) is a Fc engineered HER2-directed monoclonal antibody, increases activation of innate and adaptive anti-ERBB2 immune responses, relative to trastuzumab. Margetuximab binds to the same epitope as trastuzumab, but its Fc domain has been modified to enhance binding to activating FcγRIIIA (CD16A) and reduce its affinity for inhibitory FcγRIIB (CD32B) receptors..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $358 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | $1280 | In stock | |
| 100 mg | Get quote |
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Margetuximab (MGAH22) is a Fc engineered HER2-directed monoclonal antibody, increases activation of innate and adaptive anti-ERBB2 immune responses, relative to trastuzumab. Margetuximab binds to the same epitope as trastuzumab, but its Fc domain has been modified to enhance binding to activating FcγRIIIA (CD16A) and reduce its affinity for inhibitory FcγRIIB (CD32B) receptors.
| M.Wt | ||
| Formula | Human IgG1-Kappa | |
| Appearance | Solid | |
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| Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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