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Matrine

Chemical Structure : Matrine

CAS No.: 519-02-8

Matrine (Matridin-15-one, α-Matrine)

Catalog No.: PC-24855Not For Human Use, Lab Use Only.

Matrine (Matridin-15-one) is a plant alkaloid that act as a kappa opioid receptor (KOR) and u-receptor (MOR) agonist, also directly targets Annexin A2 (ANXA2) with binding Kd of 12.8 uM, inhibits ANXA2-mediated PLG-PN conversion, shows anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Matrine (Matridin-15-one) is a plant alkaloid that act as a kappa opioid receptor (KOR) and u-receptor (MOR) agonist, also directly targets Annexin A2 (ANXA2) with binding Kd of 12.8 uM, inhibits ANXA2-mediated PLG-PN conversion, shows anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects.

Physicochemical Properties

M.Wt 248.37
Formula C15H24N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one

References

1. Wang D, et al. Chem Commun (Camb). 2017 May 2;53(36):5020-5023.

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