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Chemical Structure : Mcl-1-Puma inhibitor 8
CAS No.: 678158-55-9
Catalog No.: PC-62551Not For Human Use, Lab Use Only.
Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Mcl-1-Puma inhibitor 8 (CLZ-8) is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.
Mcl-1-Puma inhibitor 8 is a useful chemical probe to achieve safer cancer therapies by modulating Mcl-1-PUMA interaction.
| M.Wt | 393.505 | |
| Formula | C22H23N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-([1,1'-biphenyl]-4-ylmethylene)-2-(4-(2-hydroxyethyl)piperazin-1-yl)thiazol-4(5H)-one |
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1. Liu J, et al. Oncotarget. 2017 Apr 20;8(33):54236-54242.
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