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Mcl-1-Puma inhibitor 8

Chemical Structure : Mcl-1-Puma inhibitor 8

CAS No.: 678158-55-9

Mcl-1-Puma inhibitor 8 (CLZ-8)

Catalog No.: PC-62551Not For Human Use, Lab Use Only.

Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mcl-1-Puma inhibitor 8 (CLZ-8) is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.
Mcl-1-Puma inhibitor 8 is a useful chemical probe to achieve safer cancer therapies by modulating Mcl-1-PUMA interaction.

Physicochemical Properties

M.Wt 393.505
Formula C22H23N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-([1,1'-biphenyl]-4-ylmethylene)-2-(4-(2-hydroxyethyl)piperazin-1-yl)thiazol-4(5H)-one

References

1. Liu J, et al. Oncotarget. 2017 Apr 20;8(33):54236-54242.

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