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Mcl1-IN-26

Chemical Structure : Mcl1-IN-26

CAS No.: 2056238-04-9

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Mcl1-IN-26 (Mcl-1 inhibitor 26)

Catalog No.: PC-60153Not For Human Use, Lab Use Only.

Mcl-1-IN-26 is a potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Mcl-1-IN-26 is a potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays.
Mcl-1-IN-26 displays >1,000-fold selectivity over Bcl-2 and Bcl-xL.
Mcl-1-IN-26 induces cleaved caspase-3 in MV4-11 cells with IC50 of 3.78 uM.

Physicochemical Properties

M.Wt 826.45
Formula C45H52ClN5O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

1. Johannes JW, et al. ACS Med Chem Lett. 2016 Dec 27;8(2):239-244.

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