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Chemical Structure : Mdivi-1
CAS No.: 338967-87-6
Catalog No.: PC-21364Not For Human Use, Lab Use Only.
Mdivi-1 (Mitochondrial division inhibitor 1) is a selective dynamin-related protein 1 (Drp1) inhibitor and mitochondrial division/mitophagy inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 1 g | Get quote |
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Mdivi-1 (Mitochondrial division inhibitor 1) is a selective dynamin-related protein 1 (Drp1) inhibitor and mitochondrial division/mitophagy inhibitor.
Mdivi-1 inhibits Dnm1 assembly and GTPase activity in vitro.
Mdivi-1 does not affect Dynamin-1 GTPase activity in vitro and the two mitochondrial dynamin family members that mediate yeast mitochondrial fusion, Fzo1 or Mgm1.
Mdivi-1 prevents the release of cytochrome c from isolated mitochondria by cleaved Bid.
Mdivi-1 prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.
Mdivi-1 attenuates both tubular cell apoptosis and acute kidney injury in proximal tubular cells in mice during renal ischemia/reperfusion and cisplatin-induced nephrotoxicity.
| M.Wt | 353.22 | |
| Formula | C15H10Cl2N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(2,4-Dichloro-5-methoxyphenyl)-2-mercaptoquinazolin-4(3H)-one |
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1. Tanaka A, et al. Mol Cell. 2008 Feb 29;29(4):409-10.
2. Brooks C, et al. J Clin Invest. 2009 May;119(5):1275-85.
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