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Mefatinib

Chemical Structure : Mefatinib

CAS No.: 1989592-50-8

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Mefatinib (Mifanertinib dimaleate, MET306, MET-306)

Catalog No.: PC-22307Not For Human Use, Lab Use Only.

Mefatinib (Mifanertinib dimaleate, MET306, MET-306) is a potent, bioavailable, second-generation, irreversible dual inhibitor of EGFR/HER2 with IC50 of 0.4/11.7 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Mefatinib (Mifanertinib dimaleate, MET306, MET-306) is a potent, bioavailable, second-generation, irreversible dual inhibitor of EGFR/HER2 with IC50 of 0.4/11.7 nM, respectively.
    Mefatinib demonstrated similar or even better anti-tumor activity as compared with afatinib in nude mouse xenograft models of erlotinib-resistant human NSCLC NCI-H1975 harboring EGFR L858R/T790M double mutation.

    Physicochemical Properties

    M.Wt 698.01
    Formula C29H27ClF3N5O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(difluoromethoxy)-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2)

    References

    1. Wang P, et al. Signal Transduct Target Ther. 2021 Nov 1;6(1):374.

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