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Chemical Structure : Mefatinib
Catalog No.: PC-22307Not For Human Use, Lab Use Only.
Mefatinib (Mifanertinib dimaleate, MET306, MET-306) is a potent, bioavailable, second-generation, irreversible dual inhibitor of EGFR/HER2 with IC50 of 0.4/11.7 nM, respectively.
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Mefatinib (Mifanertinib dimaleate, MET306, MET-306) is a potent, bioavailable, second-generation, irreversible dual inhibitor of EGFR/HER2 with IC50 of 0.4/11.7 nM, respectively.
Mefatinib demonstrated similar or even better anti-tumor activity as compared with afatinib in nude mouse xenograft models of erlotinib-resistant human NSCLC NCI-H1975 harboring EGFR L858R/T790M double mutation.
| M.Wt | 698.01 | |
| Formula | C29H27ClF3N5O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang P, et al. Signal Transduct Target Ther. 2021 Nov 1;6(1):374.
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