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Megakaryopoiesis inducer MK1

Chemical Structure : Megakaryopoiesis inducer MK1

CAS No.: 1026307-65-2

Megakaryopoiesis inducer MK1 (MK1)

Catalog No.: PC-62019Not For Human Use, Lab Use Only.

MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.

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    Biological Activity

    MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.
    MK1 is a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells.
    MK1 also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR.

    Physicochemical Properties

    M.Wt 573.58
    Formula C30H26F3N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(7-((2,6-dimethylpyridin-3-yl)amino)-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-N-(3-(trifluoromethyl)phenyl)-4-vinylbenzamide

    References

    1. Boitano AE, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23.

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