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Chemical Structure : Megakaryopoiesis inducer MK1
Catalog No.: PC-62019Not For Human Use, Lab Use Only.
MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.
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MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.
MK1 is a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells.
MK1 also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR.
| M.Wt | 573.58 | |
| Formula | C30H26F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Boitano AE, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23.
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