Catalog No.: PC-23245Not For Human Use, Lab Use Only.
Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3).
Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3). Menadione sodium bisulfite (MSB) directly oxidizes essential cysteines on class III PI 3-kinase VPS34, thus inactivating the PI(3)P-producing enzyme. Menadione sodium bisulfite (MSB) suppresses PC progression and induces oxidative stress. MSB triggers an oxidative cell death modality. Dietary MSB improved muscle histology and function and extended life span in a myotubular myopathy model.
Physicochemical Properties
M.Wt
276.24
Formula
C11H9NaO5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Menadione sodium bisulfite
References
1. Swamynathan MM, et al. Science. 2024 Oct 25;386(6720):eadk9167.
