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Chemical Structure : Mepazine
CAS No.: 2975-36-2
Catalog No.: PC-49478Not For Human Use, Lab Use Only.
Mepazine is a potent, selective MALT1 paracaspase inhibitor with IC50 of 0.83 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $238 | In stock | |
| 250 mg | Get quote |
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Mepazine is a potent, selective MALT1 paracaspase inhibitor with IC50 of 0.83 uM.
Mepazine (5 uM) inhibited cellular MALT1 cleavage activity and significantly reduced IL-2 induction in T cells, impaired MALT1-mediated T cell activation.
Mepazine inhibited anti-apoptotic NF-κB signaling and elicit toxic effects selectively on MALT1-dependent ABC-DLBCL cells in vitro and in vivo.
| M.Wt | 346.92 | |
| Formula | C19H23ClN2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride |
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1. Nagel D, et al. Cancer Cell. 2012 Dec 11;22(6):825-37.
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