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Chemical Structure : Merck60
CAS No.: 849234-64-6
Catalog No.: PC-70123Not For Human Use, Lab Use Only.
Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively.
Merck60 displays 50-400 fold selectivity over class I HDAC3 (IC50 = 458 nM) and no appreciable inhibition of HDAC8 or of the class II HDACs (IC50>30 uM).
Merck60 alters gene expression in brain circuits involved in mood regulation, improves mood-related behaviors in mice.
| M.Wt | 351.424 | |
| Formula | C19H17N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide |
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1. Schroeder FA, et al. PLoS One. 2013 Aug 14;8(8):e71323.
2. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
3. Stubbs MC, et al. Clin Cancer Res. 2015 May 15;21(10):2348-58.
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